Cytomel is a prescription medicine used to treat symptoms of low thyroid hormone (hypothyroidism) and increased thyroid (non -toxic goose), myxedema and myxedema coma. Cytomel can be used on its own or with other medicines.
Cytomel belongs to a group of medicines called thyroid products.
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Cytomel can cause serious side effects, including:
If you have any of the above symptoms, seek medical attention immediately.
The most common side effects of Cytomel include:
Tell your doctor if you have any side effect that bothers you or does not disappear.
These are not all possible side effects of Cytomel. Consult your doctor or pharmacist for more information.
Call your doctor for side effects. You can report on the side effects of FDA on 1-800-FDA-1088.
Thyroid hormone medicines are natural or synthetic preparations containing sodium tetraiodotyronine (T4, levotyroxine) or sodium triiodothyronine (T3, Liotirononin) or both. T4 and T3 are formed in human thyroid with iodine and connect amino acid tyrosine. T4 contains four iodine atoms and is formed by joining two dyodotirosine molecules (dit). T3 contains three iodine atoms and is formed by joining one molecule of DIT with one molecule monoiodotirosine (myth). Both hormones are stored in thyroid colloid as tyroglobulin.
Thyroid hormone preparations fall into two categories: (1) natural hormonal preparations obtained from the animal thyroid gland, and (2) synthetic preparations. Natural preparations include dried thyroid and tyroglobulin. The drained thyroid dates from domesticated animals used by humans for food (either beef or thyroid pork) and thyroglobulin from the thyroid glands of the pigs. US Pharmacopea (USP) has standardized the total iodine content in natural preparations. The thyroid USP contains at least (NTLT) 0.17 percent and maximum (NMT) 0.23 percent iodine and tyroglobulin no less than (NTLT) 0.7 percent of organically bound iodine. Iodine content is just an indirect indicator of true hormonal biological activity.
Cytomel (sodium liotirononin) tablets contain liotironin (L-three or LT3), synthetic form of natural thyroid hormone, and is available as sodium salt.
Structural and empirical formulas and molecular weight of sodium liotyronin are given below.
L-tyrosine, o- (4-hydroxy-3 -jodophenyl) -3.5-dud
Twenty-five McG Liotirononin corresponds to about 1 grain of dried thyroid or thyroglobulin and 0.1 mg L-thyroxine.
Each round, white to gray Cytomel tablet (sodium liotyronin) contains sodium liotironin, which corresponds to Liotironin, as follows: 5 mcg impressed KPI and 115; 25 mcg achieved and imprinted KPI and 116; 50 mcg reached and imprinted KPI and 117. Inactive ingredients are calcium sulfate, gelatin, cornstarch, stearic acid, sucrose and talc.
Thyroid hormone medicines are indicated:
As a replacement or supplementary treatment in patients with hypothyroidism of any etiology, except with transient hypothyroidism in the recovery phase of subacute thyroiditis. This category includes cretinism, mix and ordinary hypothyroidism in patients of any age (pediatric patients, adults, elderly) or countries (including pregnancy); primary hypothyroidism resulting from functional deficiencies, primary atrophy, partial or complete absence of thyroid or surgery, radiation or medicines, with or without the presence of naked; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see Warnings ).
As thyroid stimulating hormone (TSH) pituitary glands in the treatment or prevention of various types.
As diagnostic agents in suesry tests to distinguish suspicion of mild hyperthyroidism or thyroid autonomy.
Cytomel tablets (Liotironin sodium) can be used in patients who are allergic to the drained thyroid or thyroid extract obtained from pork or beef.
Thyroid hormone dosage is determined according to the indication and in each case it must be individually adjusted according to the patient’s response and laboratory findings.
Cytomel (sodium liotironin) tablets are intended for oral use; Dose is recommended once a day. Although sodium liotironin is rapidly cut off, its metabolic effects last a few days after discontinuation of treatment.
The recommended starting dose is 25 mcg per day. The daily dose can then be increased by up to 25 mcg per 1 or 2 weeks. The usual maintenance dose is 25 to75 mcg per day.
Due to the rapid start and dispersion of the action of sodium liotyronin (T3) compared to sodium levotyroxine (T4), some doctors have given priority to its use in patients who may be more susceptible to the adverse effects of thyroid medicines. However, large fluctuations of serum t levels that follow its use and the possibility of more pronounced cardiovascular side effects usually offset these benefits.
Cytomel tablets (sodium liotyronin) can be given priority to levotyroxine (T4) during radioisotopic scan procedures because the induction of hypothyroidism in these cases is more sudden and may be shorter. It can also be better when there is a suspected malfunction of the peripheral conversion T4 in T3.
The recommended starting dose is 5 mcg per day. This can be increased by 5 to 10 mcg per day every 1 or 2 weeks. When we reach 25 mcg per day, the dose can be increased by 5 to 25 mcg every 1 or 2 weeks, until a satisfactory therapeutic response is reached. The usual maintenance dose is 50 to 100 mcg per day.
Comeda with a mixedem in long -term patients with hypothyroid gland is usually precipitated by concomitant diseases or medicines such as sedatives and anesthetics, so they should be considered as emergency medical assistance.
Intravenous sodium liotironin preparation is recommended for use in Mixedema coma / Prekmi.
The recommended starting dose is 5 mcg per day, with an increase of 5 mcg every 3 to 4 days until the desired response is reached. Babies just a few months old can only need 20 mcg a day to maintain. One year may be required 50 mcg per day. After 3 years, a full dose for adults may be required (see Preceding the precaution ; Pediatric use ).
The recommended starting dose is 5 mcg per day. This dose may be increased by 5 to 10 mcg per day every 1 or 2 weeks. When you reach 25 mcg a day, the dose can be increased by 12.5 or 25 mcg each week or two. The usual maintenance dose is 75 mcg per day.
In older or pediatric patients Treatment should start with 5 mcg per day and increase only by 5 mcg at recommended intervals.
At the passage of a patient to Cytomel tablets (sodium liotironin) From thyroid, L-thyroxine or thyroglobulin, discontinue treatment with other medicines, introduce Cytomel in small doses and gradually increase according to the patient’s response. When choosing a initial dose, remember that this medicine is quickly working and that the remaining effects of the second thyroid preparation may last for the first few weeks of treatment.
The use of thyroid hormone in doses higher than those produced by the gland physiologically causes inhibition of endogenous hormone production. This is the basis for a thyroid supression test and is used to help the diagnosis of patients with signs of mild hyperthyroidism in which baseline laboratory tests seem normal, or to prove thyroid autonomy in patients with Graves’s ophthalmopathy. The assignment is determined before and after giving the exogenic hormone. Absorption control of 50% or more indicates a normal thyroid and pituitary axis, thereby excluding thyroid autonomy.
Cytomel (sodium liotyronin) tablets are given at doses from 75 to 100 mcg / day for 7 days, and radioactive iodine intake is determined before and after the hormone administration. If thyroid function is under normal supervision, the adherence of the radio is decreased after treatment. Cytomel tablets (sodium liotyronin) should be carefully given to patients who have a strong suspicion of thyroid autonomy as the effects of exogenous hormones will be added to an endogenous source.
Cytomel tablets (Liotiron Sodium) : 5 mcg in bottles of 100; 25 mcg in bottles of 100; and 50 mcg in bottles of 100.
5 mcg 100s: Ndc 60793-115-01
25 mcg 100’s: Ndc 60793-116-01
50 mcg 100s: Ndc 60793-117-01
Store between 15 ° and 30 ° C (59 ° and 86 ° F).
Divided: Pfizer Inc, New York, 10017. Changed: June 2016
Side effects and interactions with medicines
Side effects except those indicating hyperthyroidism due to therapeutic overdose, either at the beginning or during maintenance period (see Overgrowing ). In rare cases, allergic skin reactions with Cytomel tablets have been reported (sodium liotironin).
Thyroid hormones appear to increase the catabolism of clotting factors dependent on vitamin K. If oral anticoagulants are also given, an impaired increase in blood clotting factor is a weakening. Patients stabilized on oral anticoagulants who have been found to need replacement thyroid treatment should be closely monitored at the start of treatment. If the patient is a truly hypothyroid gland, it is likely that the dose of anticoagulant will have to be reduced. Special precautions appear to be unnecessary when a patient who is already stabilized on a thyroid maintenance treatment begins orally anticoagulant treatment.
Starting replacement thyroid treatment may lead to an increase in insulin or oral hypoglycemic needs. The effects observed are poorly understood and depend on various factors such as dose and type of thyroid preparation and endocrine status of the patient. Patients receiving insulin or oral hypoglycaemia should be closely monitored during the introduction of thyroid replacement treatment.
Cholestyramine binds both T4 and T3 in the gut, thus impairing the absorption of these thyroid hormones. In vitro Studies show that bindings are not easy to remove. Therefore, during the administration.
Estrogens usually increase serum thyroxine bonding globulin (TBG). In a patient with a non -acting thyroid gland on replacement treatment of thyroid gland, free levotyroxine may be reduced at the beginning of estrogen use, which increases thyroid needs. If the patient’s thyroid has sufficient function, reduced free thyroxine will cause a compensatory increase in thyroxine production in the thyroid gland. Therefore, patients without a thyroid -free thyroid -free thyroid treatment may need to increase the dose of thyroid gland if they receive estrogen or oral contraceptives containing estrogen.
The use of thyroid products with imipramine and other tricyclic antidepressants can increase receptor sensitivity and enhance antidepressant action; transient cardiac arrhythmias. Thyroid hormone activity may also increase.
Thyroid preparations can strengthen the toxic effects of digitalis. Hormonal thyroid replacement increases metabolism rate, requiring an increase in digitalis dose.
